The below passage from On The Road contains the quintessential beat pick-up line: "What do you want out of life?" Jack even uses it again later in the novel (a gold star if a Daily Beat reader can identify the passage).
In The Beat Handbook: 100 Days of Kerouactions, I describe the two purposes behind this question. You'll have to buy, borrow, or steal my book to see what I think they are.
Tomorrow: On Courting.